The Sleeplocke challenge is a regular Nuzlocke challenge, with one added rule: the player must complete the run without falling asleep in real-life. If the player falls asleep, the run is considered failed. Technically, any variant of the Nuzlocke challenge could be used with the “no sleeping” rule added, but it is common to use the standard ruleset.
For a more comprehensive list of additional rules you can use to customize any Nuzlocke run, see our Optional Rules section. For even more unique ways to enjoy the Nuzlocke challenge, check out our Nuzlocke Variants page!